From Adipose Biology To Beyond
Recognizing the career of Professor David A Bernlohr through his trainees
Friday, May 3, 2024
10 a.m. - 3:30 p.m.
Memorial Hall, McNamara Alumni Center
Minneapolis Campus
Program
| 10 a.m. | Welcome & Introductions, Dr. Doug Mashek and Dr. David Bernlohr |
| 10:15 a.m. | Synaptic Signaling in Memory and Chronic Pain; Dr. Kimberley Fuchs-Tolias, Baylor College of Medicine |
| 11:05 a.m. | Discovery and Development of Remdesivir for the Treatment of Highly Pathogenic Emerging Viruses; Dr. Christopher Kane, National Cancer Institute, NIH |
| 12 p.m. | Lunch |
| 1 p.m. | Awards program |
| 1:30 p.m. | The Microbiome, Surgery and Metabolic Disease; Dr. Cyrus Jahansouz, University of Minnesota |
| 2:20 p.m. | FABPs and Adipose: Fat Is Where It's At; Dr. Ann Hertzel, University of Minnesota |
| 3:10 p.m. | Closing remarks; Dr. David Bernlohr, University of Minnesota |
Background for the Frederick J. Bollum Endowed Research Fund for Biochemistry Lectureship Series
Frederick J. Bollum received a B.A. in Zoology in 1949 and a Ph.D. in Physiological Chemistry in 1956 from the University of Minnesota. He went on to a Postdoctoral Fellowship at the Universtiy of Wisconsin and then took a position at Oak Ridge National Laboratory in Tennessee. Later, he became a Professor of Biochemistry at the University of Kentucky Medical School, in Lexington, KY and then Chairman of Biochemistry at Uniformed Services University for the Health Sciences, Bethesda, MD. He then moved on to become President and CEO of Supertechs, Inc., Biotechnology Consultants. His major research interests were nucleic acid chemistry and enzymology, nucleotide metabolism, genetic aspects of biochemistry, immunological diversification and recombinant DNA, authoring more than 260 papers and three books.
Dr. Bollum regularly contributes to the Department of Biochemistry, Molecular Biology and Biophysics through the Minnesota Medical Foundation. His gifts have helped support lectures, research, graduate student awards and meeting opportunities and an annual symposium on cutting edge research topics.
Archive
Year/Topic | Speaker/Affiliation | Titles |
2023 Celebrating the Legacy of Fred Bollum, Excellence in Graduate Research | Dr. Sofia Moraes
Dr. Shanley Roach
Dr. Fredrik Sadler
Dr. Kathryn Crone | Ancient genetic conflicts with the host innate immune system have shaped herpesvirus evolution in primates Clearing hurdles: understanding natural virus transmission and evolution at barrier surfaces Autoregulation of G protein-coupled receptor signaling through the third intracellular loop Biochemical and structural interrogation of a borosin RiPP system |
2021 Unnatural Biology | Dr. Jason Chin Dr. Farren Isaacs Dr. Floyd Romesberg Dr. Tanja Kortemme | Reprogramming the genetic code Genomes by design: Recoding & rewriting life’s genetic blueprint Semi-synthetic organisms that store and retrieve increased genetic information Sensors and new shapes: Computational design of new molecular geometries and ligand-controlled functions |
2019 Coupling Metabolism & Protein Post-translational Modifications (Poster) | Dr. Yingming Zhao, University of Chicago Dr. Sumin Kang, Emory University Dr. Hening Lin, Cornell University Dr. Kathryn Wellen, University of Pennsylvania | "A new paradigm of epigenetic regulation linking cell. metab. to histone marks" "Phosphorylation in metabolic signaling and cancer progression" "Regulatory roles of metabolites" "Acetyl-CoA metabolism in chromatin regulation and tumorigenesis" |
2018Mechanobiology (Poster) | Brenton Hoffman, PhD, Duke University Marcos Sotomayor, PhD, Ohio State University Matt Lang, PhD, Vanderbilt University Arpita Upadhyaya, PhD, University of Maryland Scott Manalis, PhD, Massachusetts Institute of Technology | "Assessing the effects of protein load on protein function" "Molecular mechanics of hearing" "Single molecule drivers of αβ T cell recognition" "Cytoskeletal dynamics of mechanosensing in immune cells" "Non-invasive monitoring of single-cell mechanics" |
2017Versatile Functions of RNA in Biology and Disease (Poster) |
Hashim AL Hashikmi, Ph.D. Duke University University of Rochester University of Pennsylvania Maurice Swanson, Ph.D. University of Flordia | "Dynamic RNA Structures in Translational Fidelity and Drug Discovery" "Nonsense-mediated mRNA Decay and Human Disease: Genome Guardian and Executor" "Getting Sick of Splicing: Alternative Splicing and the Human Immune System" "RNA-mediated Mechanisms in Development and Disease" |
2016Therapeutic Proteins: a Protein Engineering Perspective (Poster) | Jonathan Dordick, Ph.D. Center for Biotechnology & Interdisciplinary Studies Joanna Swain, Ph.D. Bristol-Myers Squibb Eric Gaucher, Ph.D. Parker H. Petit Institute for Bioengineering & Bioscience Hans Erickson, Ph. D. Genentech | "Biomolecular engineering as an emerging paradigm for advancing medicine" "In vitro selection coupled with NGS in therapeutic protein discovery at Bristol-Myers Squibb" "Engineering ancient proteins for biotherapeutic development" "Building better antibody-drug conjugates for the treatment of cancer" |
2015Biochemistry Centennial Celebration (Poster) | Dr. Hung-Ying Kao (Ph.D., 1995) Dr. Amy Rocklin (Ph.D., 2000) Dr. Venkateswarlu Pothapragada (Ph.D., 1962) Dr. Brad Wallar (Ph.D., 2000) Dr. Rebecca Moen (Ph.D., 2013) Dr. Melanie Simpson (Ph.D., 1997) | "Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated With the U1 snRNP" "Structural and Mechanistic Studies of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase" "Studies on Fluoride Metabolism and Transport" "Probing The Interactions Between Component B and The Hydroxylase Of Methane Monooxygenase" "Site-directed Modifications of Myosin" "Biochemical and Physiological Analysis of the Adipocyte Lipid-binding Protein" |
2014The dynamic microbiome | Mount Sinai School of Medicine Lawrence David, PhD Duke University University of Minnesota-Twin Cities Michael Sadowsky University of Minnesota-Twin Cities | "From population studies to inflammation and cancer: the microbiome in health and disease" "Perturbing Human Microbiota" "Linking microbiome structure and function to host phenotype and genotype" "Use of Fecal Microbiota Therapeutics to Treat and Understand Intestinal Dysbiosis" |
2013Discovery Metabolomics | University of California, Davis University of Michigan University of Utah School of Medicine Gary Siuzdak, PhD The Scripps Research Institute | "The NIH West Coast Metabolomics Center: Integrating metabolomics with genomic data" "NMR-based Metabolomics for Cancer Biomarker Discovery" "The Integrated Regulation of Metabolism" "Mass Spectrometry-Based Global Metabolomics for Understanding Disease Pathogenesis" |
2012Structure, Motion, Biomarkers: Discovery through NMR (Poster) | Prof. Dorothee Kern, Brandeis University Prof. Jeremy K. Nicholson, Imperial College, London Prof. Chad M. Rienstra, University of Illinois Prof. Gerhard Wagner, Harvard University | Choreographing an enzyme's dance-dynamics during catalysis Spectroscopy and Stratified Medicine: Getting Systems Biology into the Clinic Taking solid-state NMR to extremes: membrane proteins, fibrils, new methods New NMR experiments for challenging proteins |
2011Biophysics of Nucleic Acid-Protein Interactions (Poster) | Dr. Michael Fried, University of Kentucky, Lexington, KY Dr. Ioulia Rouzina, University of Minnesota, Minneapolis, MN Dr. Phillip A. Sharp, Massachusetts Institute of Technology, Cambridge, MA Dr. Mark C. Williams, Northeastern University, Boston, MA | O6 Alkylguanine-DNA Alkyltransferase. New Functions For A Guardian of the Genome. Bloomfield-Inspired Biophysics in HIV Research From Biophysics to RNA Biology Mechanochemistry of DNA binding: From small molecules to proteins |
2010Unconventional Nucleic Acid Biology | Dr. Brenda Bass, University of Utah, Salt Lake City, UT Dr. Ronald Breaker, Yale University, New Haven, CT Dr. Simon Wain-Hobson, Pasteur Institute, Paris, France Dr. Michael Neuberger, University of Cambridge, Cambridge, UK | Toward a mechanistic understanding of Dicer's different roles in processing dsRNA. Riboswitches- Molecular Relics from the RNA World?
The pros and cons of viral hypermutation.
Antibody diversification through DNA deamination. |
2009The Biochemistry of Biofuels
| Dr. Timothy Donohue, University of Wisconsin-Madison Dr. Jay Keasling, University of California, Berkeley Dr. James C. Liao, University of California, Los Angeles Dr. Stephen Ragsdale, University of Michigan, Ann Arbor | Tapping into Microbial Genomes for Light-driven Hydrogen Production. Engineering Microorganisms for Production of Advanced Biofuels. Fuels and Chemical Beyond Petroleum. Nickel Enzymes in the Biochemistry of Biofuels.
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2008Circadian Clocks | Dr. Steve A. Kay, University of California, San Diego Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School Dr. Joseph S. Takahashi, HHMI/Northwestern University Dr. Ying-Hui Fu, University of California, San Francisco | Network Discovery Pipelines for Circadian Clocks. Molecular Biology of Circadian Rhythms in Drosophila. Genetic Analysis of Circadian Clocks in Mammals. Molecular Characterization of Human Sleep Variants. |
2007Reguating Biological Function by Ubiquitination | Dr. Rachel Klevit, University of Washington, Seattle, WA
| Recognition and Disassembly of the Polyubiquitin Targeting Signal. Structural Insights into Diversity and specificity in Protein Ubiquitination. Regulation of Protasome Activity. |
2006The Science of Aging | Dr. Leonard P. Guarante, MIT, Boston Dr. Holly Van Remmen, University of Texas, San Antonio | SIR2, Calorie Restriction and Aging Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Size, Stress, and Aging: Lessons from Dwarf Mice Caloric Restriction and Aging: Studies in Mice and Monkeys |
2005Computational Biochemistry and Molecular Biology | Dr. Eric D. Siggia, Rockefeller University in New York Dr. Peter D. Karp, Stanford Research Institute International (SRI), Palo Alto (CA) Dr. Michael A. Savageau, University California, Davis. Dr. Jiali Gao, University of Minnesota | Computation Approaches to Blastoderm Patterning in the Fly and its Evolution. Databases and Algorithms for Pathway Bioinformatics. System Design Principles and Construction of Gene Circuits Dynamics, Pathways, and Tunneling: A Computational Perspective of Enzyme Catalysis |
2004Proteomics: Advancing Our Understanding of Biology
| Michel Desjardins, Université de Montréal Tim Haystead,Duke University Medical Center Kathryn E. Howell Bradford W. Gibson | Proteomics Brings New Paradigms to Immunology New Insights into Golgi Function Through Proteomics The Mitochondrial Proteome, Neurodegenerative Disease and Aging |
2003Structural Dymamics of Membrane Signal Transduction
| Dr. Wayne Hubbell, Jules Stein Eye Institute, UCLA Dr. Lynmarie Thompson, University of Massachusetts, Amherst Dr. John Spudich, University of Texas, Houston Dr. David Farrens, Oregon Health and Science University | A nitroxide's view of rhodopsin structure, dynamics and activation Site-directed solid-state NMR probing transmembrane signaling mechanisms in bacterial chemoreceptors. Microbial rhodopsins: structure/function in ion transport and signaling. Conformational changes in G-protein coupled receptors: insights gained from site-directed fluorescence studies. |
2002Nature's Copier: the DNA Replication Machinery | Dr. Melvin DePamphilis, National Institute of Child Health and Human Development Dr. Bik-Kwoon Tye, Cornell University
| The ORC Cycle: a Novel Mechanism for Regulating Eukaryotic DNA Replication Coordination of Genome Expression and DNA Replication in Proliferating Cells: The Multiple Roles of the MCM Proteins in Eukaryotes Toward a Structural Understanding of DNA Replication Initiation |
2001Directed Evolution of Biomolecules & Functional Genomics | Dr. Jeremy Minshull, Maxygen Dr. Karl Dane Wittrup, Massachusetts Institute of Technology Dr. George Georgiou, University of Texas
| Biological Diversity: From Nature and Beyond. Engineering Protein Recognition, Stability, and Expression by Yeast Display Functional Expression of Multidisulfide Proteins in |
2000G Protein-Coupled Signaling | Nigel Bunnett, University of California, San Francisco Linda Hicke, Northwestern University John Tesmer, University of Texas
| How Proteases Talk to Cells: A Comparison of Signaling by Proteases and Neuropeptides Role of Ubiquitin in Signaling Receptor Downregulation Effector Regulation by Heterotrimeric G Proteins: Lessons Learned from Adenyl Cyclase Protein Gated Potassium Channels |
1999Transcription Factors & Metabolic Control | Gretchen J. Darlington, Baylor College of Medicine Timothy S. Osborne, University of California, Irvine | The Role of C/EBP Proteins in Integratie Metabolism PPARs and PXR: Orphan Nuclear Receptors that Define Novel Hormone Signaling Pathways. Positive and Negative Regulation of Genes that Regulate Cholesterol Metabolism. |
